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Limonene and linalo...
Limonene and linalool hydroperoxides review: Pros and cons for routine patch testing
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- Ogueta, I. A. (author)
- Autonomous University of Barcelona,Pontifical Catholic University of Chile
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- Bråred Christensson, Johanna, 1965 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology
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- Gimenez-Arnau, E. (author)
- University of Strasbourg
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- Brans, R. (author)
- University of Osnabrück
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- Wilkinson, M. (author)
- Leeds Teaching Hospitals NHS Trust
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- Stingeni, L. (author)
- University of Perugia
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- Foti, C. (author)
- University of Bari Aldo Moro
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- Aerts, O. (author)
- Antwerp University Hospital
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- Svedman, Cecilia (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital
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- Goncalo, M. (author)
- University of Coimbra
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- Gimenez-Arnau, A. (author)
- Autonomous University of Barcelona
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(creator_code:org_t)
- 2022-02-23
- 2022
- English.
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In: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 87:1, s. 1-12
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Abstract
Subject headings
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- Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized products. An association between a positive clinical history and a strong patch test reaction has been described, but problems with doubtful/irritant reactions have also been reported. Considering the high frequency of relevant positive reactions, the incorporation of Lim-OOHs 0.3% and Lin-OOHs 1% in the baseline series may be justified. Since exposure, sensitization, and elicitation limits of Lim-OOHs and Lin-OOHs in the products still need to be better determined, an assessment of previous exposure, possible sensitizations, and reactions may help to improve the clinical assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- allergic contact dermatitis
- hydroperoxides
- limonene
- linalool
- patch
- test
- fragrance contact allergens
- oxidized limonene
- essential oils
- allylic
- hydroperoxides
- lavender oil
- dermatitis
- autoxidation
- exposure
- sensitization
- products
- Allergy
- Dermatology
- patch test
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Ogueta, I. A.
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Bråred Christens ...
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Gimenez-Arnau, E ...
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Brans, R.
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Wilkinson, M.
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Stingeni, L.
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show more...
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Foti, C.
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Aerts, O.
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Svedman, Cecilia
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Goncalo, M.
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Gimenez-Arnau, A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Contact Dermatit ...
- By the university
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University of Gothenburg
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Lund University